Psilocybin
Bryan Johnson: a 5‑gram dose of dried psilocybin mushrooms, monthly, Nov 2025
- 5 g dried Psilocybe cubensis containing ~25 – 30 mg psilocybin
- for 3 months
- Antidepression affects
- Longevity rat study
- Psilocybin treatment extends cellular lifespan and improves survival of aged mice
- Improved physiological condition (e.g., better fur quality and hair growth)
- 15 mg/kg per month (5 mg/kg first month) for 10 months
- For humans, body-surface-area scaling is to divide by 12.3 = 1.22mg/kg
- Typical Psilocybe cubensis ≈ 0.5–1.0% psilocybin
Trip
- last from three to eight hours
- first 3–4 hours after ingestion are typically referred to as the 'peak'
- the user experiences more vivid visuals and distortions in reality